PDB ID: 1EVZ Protein ID:Q4Q7J1 Organism:Leishmania Mexicana Etiological Risk Group: Leishmania Disease: When a sandfly of the region of the tropics, subtropics, and southern Europe lands on the victim and releases the early form of the protozoan parasite as the promastigote and allows the the parasite to grow until the cell enters phagocytes and then continues the cycle. the infection manifests itself as a cutaneous form of leishmaniasis and skin abrasions. Homology: Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania Essentiality: This plays a role in the life cycle of trypanosomes, which are what manifest this infection by going through the life cycle. By halting the promastigote stage of the life cycle the infection could halt growth before the infections spreads throughout the skin. Druggable Target: GDPH strands of this protein utilize NAD to catalyze various processes within the protein complex, such as interference with the blood stream in order to prevent against sleeping sickness. Assayable Enzyme Target: https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Enzyme_Assay/aglycerophosdehydro.pdf Protein Image:
Figure 1: PyMol accessible protein crystal 3D structure
Pairwise Alignment: Inhibitors: n/a Expression: via E.Coli Links:
E.C. Number: 1.1.1.8
Gene #: 13450683
Gene symbol: LMXM_28_3010
Genomic Sequence: NC_018332.1
PDB ID: 1EVZ
Protein ID: Q4Q7J1
Organism: Leishmania Mexicana
Etiological Risk Group: Leishmania
Disease: When a sandfly of the region of the tropics, subtropics, and southern Europe lands on the victim and releases the early form of the protozoan parasite as the promastigote and allows the the parasite to grow until the cell enters phagocytes and then continues the cycle. the infection manifests itself as a cutaneous form of leishmaniasis and skin abrasions.
Homology: Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania
Essentiality: This plays a role in the life cycle of trypanosomes, which are what manifest this infection by going through the life cycle. By halting the promastigote stage of the life cycle the infection could halt growth before the infections spreads throughout the skin.
Druggable Target: GDPH strands of this protein utilize NAD to catalyze various processes within the protein complex, such as interference with the blood stream in order to prevent against sleeping sickness.
Assayable Enzyme Target:
https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Enzyme_Assay/aglycerophosdehydro.pdf
Protein Image:
Pairwise Alignment:
Inhibitors: n/a
Expression: via E.Coli
Links:
https://www.ncbi.nlm.nih.gov/pubmed/20554795
http://www.genedb.org/web-artemis/?src=LmxM.28&base=1123437&bases=4640
http://www.genedb.org/gene/LmxM.28.3010
https://www.ncbi.nlm.nih.gov/gene/13450683
https://www.bing.com/search?q=%09Leishmania+mexicana+family&form=IENTHT&mkt=en-us&httpsmsn=1&refig=c41d930950eb4c59aa54cb4275f553d0&sp=-1&pq=leishmania+mexicana+family&sc=0-26&qs=n&sk=&cvid=c41d930950eb4c59aa54cb4275f553d0
https://gold.jgi.doe.gov/organism?id=Go0002400
http://www.uniprot.org/proteomes/UP000007259
http://tritrypdb.org/tritrypdb/app/record/gene/download/LmxM.28.3010
Gene availability:http://www.uniprot.org/proteomes/UP000007259
https://www.ncbi.nlm.nih.gov/gene/13450683
CDS Gene Sequence:
Protein Sequence:
>1EVZ:A|PDBID|CHAIN|SEQUENCE
MSTKQHSAKDELLYLNKAVVFGSGAFGTALAMVLSKKCREVCVWHMNEEEVRLVNEKRENVLFLKGVQLASNITFTSDVE
KAYNGAEIILFVIPTQFLRGFFEKSGGNLIAYAKEKQVPVLVCTKGIERSTLKFPAEIIGEFLPSPLLSVLAGPSFAIEV
ATGVFTCVSIASADINVARRLQRIMSTGDRSFVCWATTDTVGCEVASAVKNVLAIGSGVANGLGMGLNARAALIMRGLLE
IRDLTAALGGDGSAVFGLAGLGDLQLTCSSELSRNFTVGKKLGKGLPIEEIQRTSKAVAEGVATADPLMRLAKQLKVKMP
LCHQIYEIVYKKKNPRDALADLLSCGLQDEGLPPLFKRSASTPSKL